TABLE 3.
Adjusted and Unadjusted Associations of Lipid-Rich Necrotic Core in the Superficial Femoral Artery With Subsequent Lower Extremity Peripheral Artery Disease Events, Acute Coronary Events, Ischemic Stroke, and All-Cause Mortality
| Model 1, Unadjusted | Model 2, Fully Adjusted | |||
|---|---|---|---|---|
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| Hazard Ratio (95% CI) | p Value | Hazard Ratio (95% CI) | p Value | |
| Lower extremity PAD events | ||||
|
| ||||
| Any PAD event* | 2.15 (1.30–3.54) | 0.003 | 2.18 (1.27–3.75) | 0.005 |
| Any PAD event excluding revascularization† | 2.16 (1.12–4.16) | 0.021 | 2.58 (1.25–5.33) | 0.010 |
| Lower extremity revascularization | 2.47 (1.30–4.70) | 0.006 | 2.42 (1.20–4.86) | 0.013 |
| Amputation or hospitalization for critical limb ischemia. | 3.12 (0.78–12.49) | 0.107 | 2.75 (0.56–13.61) | 0.215 |
| ABI decline >0.15 | 1.68 (0.80–3.53) | 0.169 | 2.20 (0.97–5.01) | 0.06 |
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| Coronary and cerebrovascular events and all-cause mortality | ||||
|
| ||||
| Acute coronary event, ischemic stroke, or all-cause mortality | 0.97 (0.57–1.65) | 0.911 | 0.86 (0.49–1.51) | 0.608 |
| Acute coronary events | 1.11 (0.54–2.29) | 0.771 | 0.86 (0.38–1.94) | 0.711 |
| Ischemic stroke | 0.76 (0.21–2.69) | 0.671 | 0.80 (0.21–3.10) | 0.752 |
| All-cause mortality | 1.12 (0.58–2.18) | 0.728 | 0.93 (0.45–1.89) | 0.831 |
Model 2 adjusted for age, sex, race, diabetes, hypertension, history of MI, angina, LDL-C, HDL-C, BMI, cigarette smoking, statin use, antiplatelet therapy, and baseline ABI.
Patients who experienced 1 or more lower extremity PAD events, consisting of lower extremity amputation, hospitalization for critical limb ischemia, ABI decline of >0.15, or lower extremity revascularization.
Patients with 1 or more PAD events, consisting of lower extremity amputation, hospitalization for critical limb ischemia, or ABI decline of >0.15.