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. Author manuscript; available in PMC: 2017 Nov 24.
Published in final edited form as: J Pharm Pharmacol. 2008 May;60(5):615–623. doi: 10.1211/jpp.60.5.0007

Table 2.

Pharmacokinetic parameters of 5-FU after administration of colon-specific microspheres and immediate-release formulation in rats. Values are mean ± s.d. (n = 3).

Parameter Microsphere formulation Immediate-release formulation
Cmax (μg mL−1) 12.51 ± 2.81 94.12 ± 5.21
Tmax (h) 17.30 ± 1.154 0.83 ± 0.280
AUC (μg h mL−1) 104.14 ± 8.42 150.10 ± 11.58
Mean residence time (h) 15.50 ± 2.73 1.78 ± 0.31
Relative bioavailability (%) 69.37 ± 7.49 –

Cmax, maximum plasma concentration; Tmax, time to Cmax; AUC, area under the plasma concentration–time curve (0–24 h).