Table 4.

Biochemical parameters in rats treated with immediate-release 5-FU and colon-specific microspheres. Data are mean ± s.d. (n = 6). Treatment of groups is shown in Table 1

Parameter	Group Ia	Group IIa	Group IIaa	Group IIba	Group IIca	Group IIda	Group IIea,b
WBC (mm−3)	6800 ± 234	7633 ± 665	8124 ± 561	7299 ± 360	5200 ± 655	7546 ± 790	2400 ± 264
Platelets (Lacs mm−3)	3.45 ± 0.34	5.46 ± 1.22	6.16 ± 1.01	4.55 ± 0.87	3.11 ± 0.59	4.58 ± 0.87	2.17 ± 0.56
Serum albumin (g dL−1)	1.13 ± 0.23	1.82 ± 0.32	1.67 ± 0.27	1.73 ± 0.23	2.59 ± 0.41	1.77 ± 0.23	3.89 ± 0.43
Serum creatinine (mg dL−1)	0.356 ± 0.04	0.656 ± 0.08	0.603 ± 0.05	0.659 ± 0.07	0.749 ± 0.04	0.652 ± 0.04	0.948 ± 0.06
Alkaline phosphatase (IU L−1)	21.5 ± 4.6	81.2 ± 20.5	96.2 ± 17.7	70.2 ± 15.3	147.2 ± 18.0	65.7 ± 11.3	571.5 ± 45.3
SGOT (IU L−1)	15.5 ± 2.6	81.8 ± 12.5	75.9 ± 15.1	62.3 ± 17.6	147.5 ± 14.6	55.1 ± 9.0	228.0 ± 27.4
SGPT (IU L−1)	22.3 ± 5.5	48.7 ± 7.2	52.4 ± 6.3	37.5 ± 8.3	116.5 ± 18.6	38.12 ± 8.6	265.5 ± 28.3

SGOT, serum glutamate oxloacetate transaminase; SGPT, serum glutamate pyruvate transaminase.

^aValues after 14 weeks;

^bn = 4.