Table 4.
Biochemical parameters in rats treated with immediate-release 5-FU and colon-specific microspheres. Data are mean ± s.d. (n = 6). Treatment of groups is shown in Table 1
| Parameter | Group Ia | Group IIa | Group IIaa | Group IIba | Group IIca | Group IIda | Group IIea,b |
|---|---|---|---|---|---|---|---|
| WBC (mm−3) | 6800 ± 234 | 7633 ± 665 | 8124 ± 561 | 7299 ± 360 | 5200 ± 655 | 7546 ± 790 | 2400 ± 264 |
| Platelets (Lacs mm−3) | 3.45 ± 0.34 | 5.46 ± 1.22 | 6.16 ± 1.01 | 4.55 ± 0.87 | 3.11 ± 0.59 | 4.58 ± 0.87 | 2.17 ± 0.56 |
| Serum albumin (g dL−1) | 1.13 ± 0.23 | 1.82 ± 0.32 | 1.67 ± 0.27 | 1.73 ± 0.23 | 2.59 ± 0.41 | 1.77 ± 0.23 | 3.89 ± 0.43 |
| Serum creatinine (mg dL−1) | 0.356 ± 0.04 | 0.656 ± 0.08 | 0.603 ± 0.05 | 0.659 ± 0.07 | 0.749 ± 0.04 | 0.652 ± 0.04 | 0.948 ± 0.06 |
| Alkaline phosphatase (IU L−1) | 21.5 ± 4.6 | 81.2 ± 20.5 | 96.2 ± 17.7 | 70.2 ± 15.3 | 147.2 ± 18.0 | 65.7 ± 11.3 | 571.5 ± 45.3 |
| SGOT (IU L−1) | 15.5 ± 2.6 | 81.8 ± 12.5 | 75.9 ± 15.1 | 62.3 ± 17.6 | 147.5 ± 14.6 | 55.1 ± 9.0 | 228.0 ± 27.4 |
| SGPT (IU L−1) | 22.3 ± 5.5 | 48.7 ± 7.2 | 52.4 ± 6.3 | 37.5 ± 8.3 | 116.5 ± 18.6 | 38.12 ± 8.6 | 265.5 ± 28.3 |
SGOT, serum glutamate oxloacetate transaminase; SGPT, serum glutamate pyruvate transaminase.
a
Values after 14 weeks;
b
n = 4.