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. Author manuscript; available in PMC: 2018 Dec 15.
Published in final edited form as: Exp Cell Res. 2017 Oct 26;361(2):265–276. doi: 10.1016/j.yexcr.2017.10.026

Fig. 9.

Fig. 9

Model of VANGL2-dependent regulation of cell-ECM adhesion. When VANGL2 is present at the plasma membrane it promotes cell-ECM adhesion through inhibition of MMP14/MMP2 activity and positive regulation of integrin αvβ3 expression. Without VANGL2, increased MMP14/MMP2 activity and decreased integrin αvβ3 expression inhibits cellular adhesion to the ECM. It remains unclear whether VANGL2 regulates integrin αvβ3 expression directly or through effects on MMP14/MMP2 activity and cleavage of ECM proteins.