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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Neural Transm (Vienna). 2017 May 24;125(3):431–447. doi: 10.1007/s00702-017-1735-6

Fig. 3. Glutamatergic terminals and SPNs dendritic spines in the striatum of control and MPTP-treated monkeys.

Fig. 3

a, b: Electron micrographs of dendritic spines and their corresponding glutamatergic synapses in the striatum of control (a), and MPTP-treated parkinsonian (b) monkeys. a.1, a.2, b.1, b.2: Three-dimensional reconstructions of vGluT1-positive terminals forming axo-spinous synapses in the striatum of control (a.1; a.2) and MPTP-treated parkinsonian (b.1; b.2) monkeys. c: Histograms comparing the quantitative analysis of morphometric parameters (spine head volume, postsynaptic density area, terminal volume) of 3D-reconstructed axo-spine corticostriatal (vGluT1, c) and thalamostriatal (vGluT2, d) synapses in the striatum of control and parkinsonian (c, d) monkeys. In MPTP-treated parkinsonian monkeys (N=3), the spine volume (Vol Spi, μm3), the areas of the postsynaptic densities (PSDs, μm2) and the volume of the presynaptic terminals (μm3) at corticostriatal (c) and thalamostriatal (d) synapses are significantly increased (*, t-test, P<0.001; SigmaPlot) in MPTP-treated monkeys compared with controls (N=3). Scale bar in a (applies to b): 1μm.