Table 1.

Kinetic parameters of vicagrel hydrolysis by recombinant esterases and human tissue microsomes.

Enzyme	Km	Vmax	CLint
Source	μM	nmol/min/mg protein	mL/min/mg protein
HLM	7.18 ± 0.66	917.6 ± 23.5	127.8 ± 9.4
HIM	6.54 ± 0.45	347.2 ± 6.4	53.1 ± 1.04
CES1	9.12 ± 1.25	264.0 ± 16.6	29.0 ± 2.3
CES2	7.19 ± 0.16	331.2 ± 14.9	46.1 ± 3.1
AADAC	9.79 ± 1.35	381.7 ± 24.7	39.0 ± 3.1
DIM	8.37 ± 0.69	171.4 ± 3.9	20.5 ± 1.3