Table 2.
MIC and ECOFF values of various antibiotics against MSSA, FICI values of those antibiotics combined with F105 and EC50 of F105 reducing twice the MIC of the appropriate antibiotic.
| MICa | ECOFFa | FICImin | EC50a | |
|---|---|---|---|---|
| Benzalkonium chloride | 1.00 | ND | 0.29 ± 0.09b | 0.5 |
| Amikacin | 1.00 | 8.00 | 0.33 ± 0.04 | 0.7 |
| Gentamicin | 1.00 | 2.00 | 0.33 ± 0.16 | 0.7 |
| Kanamycin | 2.00 | 8.00 | 0.44 ± 0.17 | 1.3 |
| Tetracycline | 0.50 | 1.00 | 0.65 ± 0.10 | 4.3 |
| Erythromycin | 1.00 | 1.00 | 0.79 ± 0.19 | 4.9 |
| Ciprofloxacin | 0.50 | 1.00 | 0.68 ± 0.27 | 5.3 |
| Ampicillin | 0.25 | ND | 0.78 ± 0.23 | 7.1 |
| Rifampicin | 0.03 | 0.03 | 0.55 ± 0.02 | 8.3 |
| Daptomycin | 4.00 | 1.00 | 0.51 ± 0.01 | 9.5 |
| Linezoild | 4.00 | 4.00 | 0.55 ± 0.01 | 7.5 |
| Vancomycin | 2.00 | 2.00 | 0.92 ± 0.14 | 7.9 |
aThe concentrations are given in mg/L; bFICI is given by the mean ± SD.