Table 4.

ROC analysis for 2.5-year MACEs among patients with separate level of renal function

Parameters	AUC	95% CI	P value	Threshold	Sensitivity, %	Specificity, %
eGFR>90 mL/min×1.73 m2 (n=244)
Δapelin-12	0.524	0.459 to 0.588	0.5556	20%	90.57	29.84
apelin-12	0.664	0.601 to 0.723	0.0001*	0.65	66.04	58.12
eGFR	0.508	0.443 to 0.572	0.8634	91.67	100	7.33
LVEF	0.628	0.564 to 0.689	0.0039*	50%	62.26	61.78
eGFR<90 mL/min×1.73 m2 (n=220)
Δapelin-12	0.566	0.498 to 0.633	0.0885	20%	92.31	31.61
apelin-12	0.654	0.587 to 0.716	0.0001*	0.89	67.69	60.65
eGFR	0.562	0.494 to 0.629	0.1186	86.13	96.92	19.35
LVEF	0.561	0.492 to 0.627	0.1651	51%	63.08	48.39

*Statistically significant value compared with apelin-12 (P<0.05).

AUC, area under curves; eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction; MACEs, major adverse cardiovascular events; ROC, receiver operating characteristic.