Table 5.

Summary judgements on the appropriateness of 349 discordant strong recommendation based on low certainty in effect in UpToDate

	n(%)
Appropriate discordant recommendations (consistent with GRADE)
1. Life-threatening (or catastrophical) situation	70(20.1)
2. Uncertain benefit, certain harm	28(8.0)
3. Potential similar benefits, one clearly less risky (or costly)	56(16.0)
4. Established similar benefits, one potentially more risky (or costly)	18(5.2)
5. Potential catastrophic harm	32(9.2)
Total	204(58.5)
Inappropriate discordant recommendations (inconsistent with GRADE)
6. Good practice statement	47(13.5)
7. Misclassification of certainty (judged moderate or high)	38(10.9)
8. Lack of explanation, should have been weak recommendation (GRADE 2C)	60(17.2)
Total	145(41.5)

GRADE, Grading of Recommendations Assessment, Development and Evaluation.