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Insulin-stimulated glucose transporter-4 (GLUT4) vesicle translocation to the skeletal muscle transverse tubules and sarcolemmal membranes. Insulin binds to the extracellular subunits of the insulin receptor (IR) that activates the phosphoinositide-3-kinase (PI3K) signaling cascade and stimulates the translocation of a pool of GLUT4 storage vesicles (GSVs) to both transverse tubule and the sarcolemmal membranes.
