Table 1.
Current clinical trials of FLT3 inhibitors in children and adults with AML.
| Drug | Clinical trial number (pediatric) | Clinical trial number (adult) | Phase of testing | Reference |
|---|---|---|---|---|
| Midostaurin | NCT00866281a (ITCC-024, CPKC412A2114) | NCT00045942 | 1, 2 (with HSCT) | Zwaan et al. (41)a Stone et al. (42)b Stone et al. (43)c |
| NCT00651261b,c | ||||
| NCT01093573 | ||||
| NCT01477606 | ||||
| NCT01830361 | ||||
| NCT01846624 | ||||
| NCT01883362 | ||||
| NCT02634827 | ||||
| Lestaurtinib | NCT00469859 (COG AAML06P1) | NCT00030186 | 1, 2 | Levis et al. (44)d |
| NCT00079482d | ||||
| Sorafenib | NCT00908167e | NCT00373373 | 1, 2, 3 (with HSCT) | Inaba et al. (45)e Widemann et al. (46)f Rollig et al. (47)g Chen et al. (48)h Ohanian et al. (49)i |
| NCT01371981 (COG AAML1031) | NCT00542971 | |||
| NCT01445080f (COG ADVL0413) | NCT00893373g | |||
| NCT01398501h | ||||
| NCT02156297 | ||||
| NCT02196857i | ||||
| NCT02867891 | ||||
| Sunitinib | None | NCT00783653j | 1,2 | Fiedler et al. (50)j |
| Fiedler et al. (51) | ||||
| Quizartinib | NCT01411267k (TACL T2009-004) | NCT00462761l | 1, 2, 3 | Cooper et al. (52)k Cortes et al. (53)l Perl et al. (54)m Schiller et al. (55)n |
| NCT00989261m | ||||
| NCT01390337 | ||||
| NCT01468467 | ||||
| NCT01565668n | ||||
| NCT02668653 | ||||
| NCT02984995 | ||||
| Ponatinib | None | NCT00660920o | 1, 2 | Cortes et al. (56)o |
| NCT02428543 | ||||
| Crenolanib | NCT02270788 (SJCRH RELHEM2) | NCT01522469p | 1, 2, 3 (with HSCT) | Cortes et al. (57)p Galanis et al. (58)q |
| NCT01657682q | ||||
| NCT02283177 | ||||
| NCT02298166 | ||||
| NCT02400255 | ||||
| NCT02400281 | ||||
| Gilteritinib | None | NCT02014558r,s | 1, 2, 3 (with HSCT) | Perl et al. (59)r Altman et al. (60)s Cortes et al. (61)t |
| NCT02421939 | ||||
| NCT02752035t | ||||
| NCT02927262 | ||||
| NCT02997202 | ||||
| NCT03070093 | ||||
COG, Children’s Oncology Group; HSCT, hematopoietic stem cell transplantation; ITCC, Innovative Treatments for Childhood Cancer European consortium; NCT, clinicaltrials.gov trial number; SJCRH, St. Jude Children’s Research Hospital; TACL, Therapeutic Advances in Childhood Leukemia and Lymphoma consortium.
Corresponding clinical trial publications or abstracts are annotated with superscripted characters for each inhibitor where available.