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Calculation of the study’s required sample size
| Sample size calculation | |
| Test: two-tailed t-test difference between two independent groups | |
| Power | 80% |
| α | 0.05 |
| Estimated effect size d | 0.6 |
| Estimate group allocation ratio N2/N1 (36% deterioration) |
0.36 |
| Calculated sample size | 114 |
| Corrections | |
| Estimated loss to follow-up | +20% |
| Estimated dysrhythmia | +10% |
| Subgroup analysis for pneumosepsis and urosepsis (70% of patients) |
+30% |
| Required sample size | 171 |
