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. 2017 Nov 25;12:101. doi: 10.1186/s13019-017-0661-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A custom-designed and -produced vascular bioreactor system. a, the design of the vascular bioreactor system. b, the processing chamber used for specimen fixation. c, operation of the dynamic vascular bioreactor system. The dynamic vascular bioreactor system was placed into a tissue culture incubator. The height difference between culture solutions was regulated to control the static pressure within the vascular grafts. A controlled peristaltic pump regulated the dynamic pressure within the vascular grafts and the flow rate variation of the culture solutions. The arrows show the operation of the dynamic vascular bioreactor system