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. 2017 Nov 1;144(21):4026–4036. doi: 10.1242/dev.151068

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© 2017. Published by The Company of Biologists Ltd

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Fig. 3. — PDGFRα activation leads to premature closure of coronal sutures and ectopic cartilage formation. (A-F) AP staining on coronal sections of control littermate and Pdgfra^+/K; Meox2Cre embryos at E13.5 (A,B), E14.5 (C,D) and E15.5 (E,F) at comparable levels (n=4 for each stage). Arrows point to the boundaries of thickening frontal bones and parietal bones in Pdgfra^+/K; Meox2Cre embryo at E15.5. (G-L) Alcian Blue (AB) staining on parallel coronal sections of control littermate and Pdgfra^+/K; Meox2Cre embryos at E13.5 (G,H), E14.5 (I,J) and E15.5 (K,L). Sections were counterstained with nuclear Fast Red (NFR). Arrows point to ectopic cartilage formed in Pdgfra^+/K; Meox2Cre embryos (H,J). CS, coronal suture; CS*, fused coronal suture; F, frontal bone; P, parietal bone. Scale bars: 50 μm.