Table 1.

Baseline characteristics

Variable	Control (n = 14)	HVHF (n = 23)	p value
Age	47 (37, 62)	50 (42, 60)	0.83
Gender (% male)	75.6	73.9	1
%TBSA	45 (29, 58)	45 (30, 60)	0.98
Inhalation (%)	36	30	1
ISS	26 (25, 47)	25 (21, 44)	0.75
ARDS (%)	57	43	0.51
MODS score	10 (9, 12)	10 (7, 14)	0.94
APACHE II score	32 (24, 35)	28 (25, 34)	0.63
MAP	70 (66, 85)	75 (64, 82)	1.00
HR	115 (101, 120)	102 (91, 116)	0.18
Hemoglobin	7.7 (7.4, 8.4)	8.2 (7.8, 9.7)	0.084
BUN	37 (32, 80)	43 (29, 50)	0.38
Creatinine	1.3 (1.1, 3.3)	2.5 (1.2, 3.1)	0.62
Lactate	1.4 (1.2, 1.6)	1.9 (1.4, 2.5)	0.22
pH	7.31 (7.25, 7.39)	7.32 (7.29, 7.38)	0.69
PFR	265 (168, 308)	211 (171, 353)	0.97
BD	–0.3 (–3.3, 1)	–2.1 (–4.3, 1.4)	0.70

Data presented as median (25th, 75th quantile) or percentage

p values from Wilcoxon two-sample tests for continuous variables and Fisher’s exact test for binary variables. All subjects included in summary tables via the intent-to-treat principle

HVHF high-volume hemofiltration, TBSA total body surface area, ISS Injury Severity Score, ARDS acute respiratory distress syndrome, MODS multiple organ dysfunction syndrome, APACHE Acute Physiology and Chronic Health Evaluation, MAP mean arterial pressure, HR heart rate, BUN blood urea nitrogen, PFR partial pressure of oxygen to fraction of inspired oxygen ratio, BD base deficit