Table 3.
Performance of the generic and cohort-specific signatures on different warfarin studies
| Validation cohort | Signature | R2 regression against IWPC residuals | P value of difference from the backgrounda |
|---|---|---|---|
| EUR validation | EUR, generic | 0.2 | 0.008 (e –4) |
| EUR, cohort-specific | 0.08 | 0.004 (0.05) | |
| AA, cohort-specific | 0.1 | 0.004 (0.03) | |
| AA validation | EUR, cohort-specific | 0.09 | 0.0009 (0.02) |
The R2 coefficient is measured on the IWPC residuals
P values below FDR of 0.05 are bolded
aBackground computed as random signatures. P values of shuffled signatures in parentheses