Table 1.

Cases

Case	Age, years	Sex	Smoking history	Primary symptoms	CXR	CT	p-m exposure	Estimated latency*	Drug	Impact after stopping
1	93	F	Yes	Fatigue, dyspnea	Diffuse pulmonary fibrosis	Central bronchiectasis and scarring	128	78	Venlafaxine	Improvement
2	90	F	Yes	Fatigue	No lung disease	Bilateral peripheral sub-pleural reticular opacity consistent with pulmonary fibrosis	287	72	Venlafaxine, paroxetine	Not stopped
3	92	F	No	Cough, mucous, dyspnea, wheeze	Chronic changes are again noted in both lung apices and left lower lobe Consolidation	Cylindrical bronchiectasis, ground glass opacities, fine and coarse reticulations nodularity	376	19	Duloxetine, venlafaxine	Improvement
4	75	M	Yes	Fatigue	No lung disease	Parenchymal scarring in lower lobes and pleural thickening	72	54	Duloxetine, citalopram	Not stopped
5	90	F	Yes	Dyspnea, fatigue	Left basilar scarring	Not available	161	37	Venlafaxine, duloxetine, escitalopram	Not stopped
6	91	F	No	Dyspnea, fatigue	Bilateral interstitial markings in bases suggestive of interstitial lung disease	Not available	92	11	Duloxetine	Not stopped
7	88	F	Yes	Cough, mucous, dyspnea, wheeze	Bilateral coarse peripheral reticular interstitial opacities in lower lobes	Bilateral idiopathic pulmonary fibrosis with honeycombing patchy airspace consolidation, bronchiectasis in left lung base	531	109	Fluoxetine	Improvement
8	93	F	Yes	Cough, mucous, dyspnea	Left basilar scarring/atelectasis	Chronic bronchial wall thickening, bilateral lower lobe bronchiectasis with inflammatory changes	33	19	Paroxetine	Improvement
9	91	M	No	Fatigue	Extensive interstitial markings consistent with pulmonary fibrosis	None available	26	8	Paroxetine	No change
10	85	M	Yes	Fatigue, cough, wheeze	Scarring left lung base	None available	84	35	Sertraline	Not stopped
11	86	F	Yes	Cough, fatigue, dyspnea	Extensive bilateral reticular interstitial opacity worse in periphery and lower lung zones consistent with pulmonary fibrosis	Interstitial changes in lung peripheries of upper and lower lobes, pulmonary fibrosis, honeycombing in both bases	0	Not applicable	None	Not applicable
12	85	F	Yes	Cough	None available	Peripheral fibrosis, honeycombing, traction bronchiectasis	0	Not applicable	None	Not applicable

Note:

^*Months between initial exposure and first radiological abnormality.

Abbreviations: CXR, chest X-ray; CT, computed tomography; p-m, person-month; F, female; M, male.