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. 2017 Nov 17;8:1553. doi: 10.3389/fimmu.2017.01553

Figure 4.

Figure 4

Lactobacillus casei BL23 induced antiproliferative activity and increased apoptosis. (A) Protein analysis of IL-22 in colon tumor section. (B) Real-time PCR analysis of relative expression in colic tumor sections of mRNA of caspase-7 (p = 0.058, Student’s t-test), (C) caspase-9 (p = 0.082, Student’s t-test), and (D) Bik (p = 0.028, Student’s t-test). Data are represented as the mean ± SEM of each group (n = 9 mice) for each graph. (E) Caspase 7 protein expression. Lines 1, 3, and 5 correspond to mice treated with L. casei BL23 (and protected against tumors and that expressed high levels of caspase-7 RNA) and lines 2, 4, and 6 to mice treated with PBS (not protected against tumors). Lines 1 and 2 correspond to samples treated with anti-β-actin antibodies; 3 and 4 with full caspase 7 antibodies; and 5 and 6 with antibodies recognizing the cleaved form of caspase 7.