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. 2017 Nov 25;11:114. doi: 10.1186/s12918-017-0500-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Summary of the compensatory pathways used by the MitoCore and Recon 2.2 models when simulating fumarase deficiency with the objective function of maximum ATP. (Red arrows represent reactions active in both models; purple arrows are only active in the MitoCore model; and orange arrows are only active in the Recon 2.2 model)