Fig. 3.

The effect of increasing proton leak through UCP2 during simulations of the MitoCore model on: maximum ATP production, flux through mitochondrial ATP synthase, flux through the mitochondrial ATP/ADP transporter, and flux through the mitochondrial phosphate transporter. The flux through ATP synthase is distinct from all the other fluxes that are superimposed, because there is also synthesis of mitochondrial ATP from the TCA cycle