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. 2017 Nov 25;15:238. doi: 10.1186/s12967-017-1342-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Loss of PTHLH significantly suppressed cell proliferation. a–c PTHLH deletion suppresses tumor growth. Five nude mice were injected subcutaneously with 1 × 10⁷ cells/mouse for each of the indicated stable cell lines. The results are presented as isolated tumors (a), tumor sizes (b), and tumor weights (c). d H&E staining of xenograft tumor from nude mice injected with shCtrl or shPTHLH_x cells (scale bar, 20 μm). e Representative images of Ki67, CyclinD1, and CDK4 protein expression in xenograft tumors from nude mice as assessed by immunohistochemistry (DAB staining, scale bar, 50 μm)