Table 1.
Correlation of the ICC clinicopathological features and TNM staging with PTHLH expression (related to Fig. 1)
| Variable | N | PTHLH expression in ICC (n = 108) (%) |
χ2 | p value | |
|---|---|---|---|---|---|
| High (75) | Low (33) | ||||
| Age (years) | |||||
| ≤50 | 25 | 18 (72.0) | 7 (28.0) | 0.100 | NS |
| >50 | 83 | 57 (68.7) | 26 (31.3) | ||
| Gender | |||||
| Female | 43 | 33 (76.7) | 10 (23.3) | 1.794 | NS |
| Male | 65 | 42 (64.6) | 23 (35.4) | ||
| Pathological differentiation | |||||
| I | 8 | 5 (62.5) | 3 (37.5) | 7.236 | 0.027 |
| II | 53 | 31 (58.5) | 22 (41.5) | ||
| III | 47 | 39 (83.0) | 8 (17.0) | ||
| Tumor size (cm) | |||||
| ≥5 | 71 | 49 (69.0) | 22 (31.0) | 0.018 | NS |
| <5 | 37 | 26 (70.3) | 11 (29.7) | ||
| Intrahepatic metastasis | |||||
| Yes | 44 | 24 (54.5) | 20 (45.5) | 7.768 | 0.005 |
| No | 64 | 51 (79.7) | 13 (20.3) | ||
| Distant metastasis | |||||
| Yes | 5 | 4 (80.0) | 1 (10.0) | 0.275 | NS |
| No | 103 | 71 (68.9) | 32 (31.1) | ||
| TNM | |||||
| I–II | 72 | 24 (33.3) | 48 (66.7) | 1.544 | NS |
| III–IV | 36 | 9 (25.0) | 27 (75.0) | ||
Italic values indicate significance of p value (p < 0.05)
NS not significant between any groups
Note: ICC patients were divided into PTHLH ‘High’ group and ‘Low’ group
Abbreviations: ICC, Intrahepatic cholangiocarcinoma; Differences among variables were assessed by χ2 or Fisher’s exact χ2 test