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. Author manuscript; available in PMC: 2018 Apr 19.

Published in final edited form as: Neuron. 2017 Apr 6;94(2):294–303.e4. doi: 10.1016/j.neuron.2017.03.024

Table 1.

Neonatal lethality in different Nalcn conditional knockout mice.

Cre line	Target		Animal number			Chi-square test p-value		Homozygous CKO lethality (%)

			Nalcn^flox/+ Nalcn^flox/flox	Heterozygous	Homozygous
Nestin^Cre	CNS		107	51	43	0.4777		100
Vglut2^Cre	Glutamatergic neurons		74	21	29	0.0585		100
Viaat^Cre	GABAergic neurons		131	54	38	0.0105		13.2
Chat^Cre	Cholinergic neurons		55	35	22	0.2172		0
Pet1^Cre	Serotonergic neurons		43	17	20	0.7136		0
GlyT2^Cre	Glycinergic neurons		112	61	40	0.0949		0

Atoh1^Cre	RTN		22	12	12	0.9575		0
Phox2b^Cre	RTN		74	36	35	0.9628		0

Dbx1^Cre	PreBötC		60	35	43	0.1944		32.6

En1^Cre	Rhombomere 1		76	43	42	0.7728		0

Cre line	Target	Animal number				Chi-square test p-value	Nalcn^Dbx1CKO lethality (%)	Nalcn^DCKO lethality (%)

		Nalcn^flox/flox	Nalcn^Atoh1CKO	Nalcn^Dbx1CKO	Nalcn^DCKO

Dbx1^Cre Atoh1^Cre	PreBötC RTN	18	12	17	20	0.5571	29.4	30.0

Abbreviation: CNS, central nervous system; RTN, retrotrapezoid nucleus; preBötC, preBötzinger Complex