Table 2.

Regulators of TRP channels, including chemical agents, cytokines, and chemokines.

	Agonists	Antagonists	Citations
TRPA1	Nicotine; mustard oil; cinnamaldehyde (bimodal); cannabinoids; tear gases; zinc; ginger; garlic; 4-HNE; allyl isothiocyanate (AITC); methylglyoxal; 12-lipoxygenase-derived hepoxilin A3; 5,6-epoxyeicosatrienoic acid; reactive oxygen species; bradykinin	HC-030031; AP18; camphor (bimodal)	Bandell et al., 2004; Jordt et al., 2004; McMahon and Wood, 2006; Hu et al., 2009; Talavera et al., 2009; Cao et al., 2012; Sisignano et al., 2012; Alpizar et al., 2013; Koivisto et al., 2014
TRPV1	Anandamide; NADA; capsaicin; piperin; protons; nerve growth factor (sensitization); IL-1β; IL-6; TNFα	Capsazepine; AMG 9810; AMG 517; 5’-iodo-resiniferatoxin	Ahern, 2003; Bonnington and McNaughton, 2003; Reilly et al., 2003; Petho et al., 2004; Gavva et al., 2005; McNamara et al., 2005; Doherty et al., 2007; Schafers and Sorkin, 2008; Hsu et al., 2009; Miller et al., 2009; Lawton et al., 2017
TRPV4	4α-Phorbol 12,13-didecanoate; epoxyeicosatrienoicacids; bisandrographolide; GSK1016790A	Ruthenium Red; Gd3+; La3+; RN-1734	Vriens et al., 2004; Becker et al., 2005; Smith et al., 2006; Thorneloe et al., 2008; Mendoza et al., 2010; Mergler et al., 2011; Zheng et al., 2013
TRPC3/6	Diacylglycerol; GSK1702934A	GSK417651A; GSK2293017A	Hofmann et al., 1999; Mio et al., 2007; Goel and Schilling, 2010; Quick et al., 2012; Tauseef et al., 2012; Chaudhuri et al., 2016