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. 2017 Nov 21;8:931. doi: 10.3389/fphys.2017.00931

Figure 1.

Figure 1

CA3 neuronal responses to broadband noise under different conditions. (A) Experimental setup on a rotatable plate for electrophysiological recordings. Pole: used for fixing animal's head. (B) Confocal image of hippocampus area (Left, Scale bar: 1,000 μm) and the Biocytin-labeled neuron in CA3 (indicated by the rectangle, Right: Enlarged figure, Scale bar: 100 μm). (C) CA3 neuronal spontaneous and noise-evoked responses when the animal was awake, anesthetized and recovery, respectively. Raster plotting (Left) and PSTHs (Right) under different conditions (corresponding to the red rectangles) were shown. The black bar indicated the broadband noise (duration: 50 ms including 5 ms rise/fall time, amplitude: 80 dB SPL). Dashed lines: Baseline of spontaneous discharges. Inserted: imposed waveforms of spikes. (D) Neuronal noise-evoked [upper, one-way ANOVA, multiple comparisons: LSD's test, P < 0.001 (awake-anesthetized), P = 0.003 (awake-recovery), and 0.050 (anesthetized-recovery)] and spontaneous [lower, one-way ANOVA, multiple comparisons: LSD's test, P < 0.001 (awake-anesthetized), P = 0.061 (awake-recovery), and 0.025 (anesthetized-recovery)] activities changed along with the states of the animals on recorded neurons (n = 8. Data obtained from the periods corresponding to the red rectangles in Figure 1C).