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. 2017 Nov 21;8:1548. doi: 10.3389/fimmu.2017.01548

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Copyright © 2017 Gorosito Serrán, Tosello Boari, Fiocca Vernengo, Beccaría, Ramello, Bermejo, Cook, Vinuesa, Montes, Acosta Rodriguez and Gruppi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infected muMT mice exhibit a low percentage of Foxp3⁺ Tregs. (A,C) Representative dot plots of the percentage of Foxp3⁺ cells gated on CD4⁺CD3⁺ T cells of (A) lymph nodes and (C) spleen from wild-type (WT) (n = 6) and muMT (n = 6) infected with 10,000 trypomastigotes of Trypanosoma cruzi, obtained at 15 days post infection (Dpi). Bars represent mean ± SD of the percentage of Foxp3⁺CD4⁺CD3⁺ T cells and the ratio between effectors CD4⁺ CD3⁺ T cells and Foxp3⁺ Tregs. (B,D) Expression of CTLA4, PD1, LAG3, and CD39 on Foxp3⁺CD4⁺CD3⁺ T cells of (B) lymph nodes and (D) spleen from infected WT and muMT mice obtained at 15 Dpi. Bars represent mean ± SD of inhibitory receptor expression on Foxp3⁺ Tregs, determined by geometric mean. Each symbol represents an individual mouse (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; two-tailed t-test).