Table 1.
Effect of Dichrocephala integrifolia on Escape Latency (EL) of mice using morris water maze.
| Treatments for 10 days | Dose (mg/kg) | EL (s) Day-6 | EL (s) Day-7 | EL (s) Day-8 | EL (s) Day-9 |
|---|---|---|---|---|---|
| DW + Sal | - + - | 27.37 ± 4.09∗ | 13.62 ± 1.87∗∗∗ | 12.20 ± 2.58∗∗∗ | 9.75 ± 0.30∗∗∗ |
| DW + Sco | - + 1 | 68.67 ± 12.03a | 69.91 ± 4.14c | 65.20 ± 3.38c | 78.66 ± 3.75c |
| DI + Sco | 35 + 1 | 70.96 ± 12.47a | 39.54 ± 11.49a∗∗ | 29.50 ± 4.52b | 29.04 ± 1.41c∗∗∗ |
| DI + Sco | 87.5 + 1 | 36.52 ± 8.78 | 14.58 ± 2.58∗∗∗ | 15.25 ± 0.67∗∗∗ | 13.25 ± 1.99∗∗∗ |
| DI + Sco | 175 + 1 | 41.58 ± 6.41 | 28.33 ± 0.98∗∗∗ | 24.66 ± 2.73∗∗∗ | 21.5 ± 2.01b∗∗∗ |
| DI + Sco | 350 + 1 | 36.54 ± 8.87 | 32.04 ± 2.88∗∗∗ | 14.67 ± 4.37a∗∗∗ | 19.91 ± 1.70a∗∗∗ |
| Tac + Sco | 10 + 1 | 26.29 ± 5.70∗ | 12.62 ± 2.46∗∗∗ | 10.87 ± 1.74∗∗∗ | 8.57 ± 1.88∗∗∗ |
Results are expressed as mean ± SEM for six mice, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 compare to scopolamine alone treated group (DW + Sco). ap < 0.05, bp < 0.01, cp < 0.0001 compare to control group (DW + Sal). F(6,35) = 4.366; P = 0.0022 (Day 6); F(6,35) = 16.67; P < 0.0001 (Day 7); F(6,35) = 16.67; P < 0.0001 (Day 8); F(6,35) = 136.26; P < 0.0001 (Day 9). DW, distilled water; DI, D. integrifolia; Sal, saline; Sco, scopolamine; Tac, tacrine.