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. 2017 Nov 12;2017:2198323. doi: 10.1155/2017/2198323

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Copyright © 2017 Xiangyu Deng et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a) Human NP cells showed a long spindle shape and exhibited good growth. (b) IL-1β retarded human nucleus pulposus growth over time and depending on its concentration. (c) Icariin has no promoting or inhibiting effects on cell proliferation at the concentration of 0.1 uM to 20 uM. (d) There was no cytotoxicity of icariin on cell at the concentration of 0.1 uM to 40 uM. When its concentration reached 40 uM, the cell membrane was observed to be unstable. There was significant difference between control group and 40 uM and 50 uM (^∗∗p < 0.01).