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Given 20 μg/mL of IL-1β for 48 h, human NP cells exhibited a decline in MMP. The group pretreated with icariin exhibited a stable mitochondrial membrane potential. When the PI3K/AKT pathway was blocked, this protective effect was weakened. There were significant statistical differences between groups, as labeled in the figure (∗∗p < 0.01 versus control group, ##p < 0.05 versus IL-1β group, and &&p < 0.05 versus IL-1β + icariin group).
