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. 2017 Nov 21;5:246. doi: 10.3389/fped.2017.00246

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Copyright © 2017 Gentner, Laube, Uhlig, Yang, Fuchs, Dreyhaupt, Hummler, Uhlig and Thome.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nitrite tracheal aspirates (TA) concentration in infants treated with high PCO₂ target levels compared to control target levels. Serial TA samples were obtained from PD2 to PD21. Number (n) of analyzed TA for each postnatal day and group (high PCO₂ target group/control target group): PD2 n = 27/25, PD4 n = 24/28, PD7 n = 14/17, PD14 n = 11/15, PD21 n = 11/11. Data are displayed as the mean of TA levels and SD on a logarithmic scale. Nitrite TA levels decreased with advancing postnatal age in both groups (^###p < 0.001). On PD2, PD4, PD7, and PD14, nitrite TA levels were not significantly affected by high PCO₂ target levels compared to mild hypercapnia, but on PD21 the high target group demonstrated lower nitrite TA levels (^↔p < 0.05). PD, postnatal day.