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. 2017 Apr 22;15(3):e44337. doi: 10.5812/ijem.44337

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Copyright © 2017, Research Institute For Endocrine Sciences and Iran Endocrine Society

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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Figure 1. — At around the time of pubertal onset, decreased expression of PcG proteins by DNA methylation along with histone 3 modifications increase Kiss1 mRNA expression resulting in elevated kisspeptin levels; this rise is accompanied by increased sensitivity to it and number of KISS1 neurons as well as enhancement of GPR54 signaling efficiency and expressio Abbreviations: PcG;Polycomb group, H3K9/14ac; Histon H3 acetylated at lysines 9/14, H3K4me3; Histon H3 trimethylated at lysine 4, H3K27me3; Histon H3 tri-methylated at lysine 27, E2; Estradiol.