Table 3. Lipid and Glycemic Profile at Baseline and After Six Weeks in Both Groupsa.
| Variables | Slow Weight Loss (n = 18) | Rapid Weight Loss (n =18) | Δ | ||||
|---|---|---|---|---|---|---|---|
| Baseline | End | Baseline | End | Intragroupb | Intragroupc | Intergroupd | |
| LDL (mg/dL) | 105.9 ± 34.3 | 111.8 ± 26.5 | 120.9 ± 28.7 | 108.1 ± 27.1 | 5.91 ± 30.95 | -12.8 ± 14.4f | -18.7 ± 8.04f |
| HDL (mg/dL) | 37.8 ± 5.4 | 39.7 ± 6.2 | 43.9 ± 9.5 | 45.1 ± 6.3 | 1.90 ± 5.95 | 1.16 ± 6.08 | -0.73 ± 1.99 |
| TG (mg/dL) | 145.3 ± 65.8 | 109.6 ± 50.1 | 163.8 ± 70.5 | 118.5 ± 52.3 | -35.6 ± 45.5f | -45.3 ± 56.8f | -9.66 ± 17.17 |
| VLDL (mg/dL) | 29.0 ± 13.1 | 21.9 ± 10.2 | 32.7 ± 14.1 | 23.7 ± 10.47 | -7.11 ± 9.12f | -9.05 ± 11.37f | -1.93 ± 3.43 |
| TC (mg/dL) | 172.4 ± 40.5 | 173.5 ± 35.3 | 194.2 ± 39.6 | 176.8 ± 31.4 | 1.06 ± 33.64 | -17.4 ± 19.6f | -18.4 ± 9.1 |
| FBS (mg/dL) | 95.1 ± 11.1 | 99.0 ± 6.7 | 100.8 ± 18.8 | 95.0 ± 9.8 | 3.92 ± 10.36 | -5.87 ± 11f | -9.80 ± 3.57f |
| FINS (μIU/l) | 13.2 ± 4.7 | 11.5 ± 5.4 | 11.2 ± 4.9 | 7.6 ± 4.3 | -1.96 ± 2.52f | -3.93 ± 3.61e | -0.06 ± 1.96 |
| HOMA-IR | 1.7 ± 0.6 | 1.4 ± 0.6 | 1.5 ± 0.7 | 1.0 ± 0.5 | -0.24 ± 0.6f | -0.43 ± 0.46e | -0.18 ± 049f |
| HOMA-B | 126.1 ± 26.2 | 100.7 ± 23.4 | 106.6 ± 50 | 86.9 ± 42.9 | -24.4 ± 25.8 | -18.8 ± 45.5 | 5.36 ± 41.2 |
| HOMA-S | 64.4 ± 19.5 | 79.3 ± 29.6 | 84.7 ± 48.9 | 131.7 ± 67.7 | 14.3 ± 21.2e | 44.2 ± 60.8f | 26.1 ± 35.3f |
| QUICKI | 0.32 ± 0.01 | 0.33 ± 0.02 | 0.33 ± 0.02 | 0.36 ± 0.03 | 0.01 ± 0.01f | 0.03 ± 0.03e | 1.16 ± 6.08f |
Abbreviations:TG, triglyceride; TC, total cholesterol; FBS, fasting blood sugar; FINS, fasting insulin; HOMA-IR, homeostasis model assessment insulin resistance; HOMA-B, HOMA-pancreatic beta cell function; HOMA-S, HOMA-insulin sensitivity; QUICKI, quantitative insulin sensitivity check index.
aAll values are means ± SD.
bChanges post-baseline in slow weight loss group.
cChanges post-baseline in rapid weight loss group.
dChanges between groups, for normally distributed variables, paired-samples t test and independent-sample t-test were used to investigate the differences within and between groups, respectively. For non-normally-distributed variables, the Wilcoxon signed ranks test and a Mann -Whitney U test were used to assess differences within and between groups, respectively.
eSignificant differences were assumed at P < 0.001.
fSignificant differences were assumed at P < 0.05.