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. Author manuscript; available in PMC: 2017 Nov 26.
Published in final edited form as: Environ Microbiol. 2017 Apr 3;19(5):2005–2024. doi: 10.1111/1462-2920.13719

Figure 1. Overview of the contribution of the two-component hybrid SagS to the motile-sessile and susceptible-resistance switches by P. aeruginosa cells.

Figure 1

Upon P. aeruginosa transition to surface-associated growth, SagS directly interacts with and phosphorylates the TCS BfiSR, thus enabling surface-associated cells to transition to the irreversible attachment stage (Petrova and Sauer, 2011). Moreover, transition to the irreversible attachment stage, regulated by SagS, marks the timing when surface-associated cells gain their heightened resistance to antimicrobial agents, with inactivation of sagS having been previously demonstrated to correlate with biofilm cells but not planktonic cells being more susceptible to antimicrobial agents (Gupta et al., 2013). SagS likely contributes to the activation of biofilm tolerance via c-gi-GMP and the transcriptional regulator BrlR. “?” indicates likely mechanism by which SagS contributes to biofilm development and/or biofilm tolerance.