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Schematic representation of site-specific RNase H cleavage of TRM4 mRNA directed by 2′-O-methyl RNA–DNA chimera. The target sequence of TRM4 mRNA is shown and the PTC (UAA) is indicated. The antisense TRM4 2′-O-methyl RNA–DNA chimera is also shown. d represents deoxy, and m stands for 2′-O-methyl. The arrow indicates the RNase H cleavage site.
