Table 1.

The anti-oxidant effects of EGCG in STZ-induced Diabetes and AD.

Disease	Species	STZ Injection Pattern	EGCG dose	Protective Mechanism	Reference
Diabetes	Rats	i.p.	25 mg/kg	↑SOD,↓MDA, ↓NO	Roghani and Baluchnejadmojarad, 2009
	Rats	i.p.	60 mg/kg	↑SOD,↓MDA	Roghani and Baluchnejadmojarad, 2010
	Mice	i.p.	100 mg/kg	↑pancreatic islet mass, ↓iNOS	Song et al., 2003
	Rats	i.p.	40 mg/kg	↑SOD,↓nitrite,	Baluchnejadmojarad and Roghani, 2012
	Rats	i.p.	2 g/L (in water)	↓oxidative stress (8-OHdG)	Raposo et al., 2015
	Rats	i.p.	7.6 mg/L (in water)	↓MDA, ↑glutathione peroxidase	Mostafa et al., 2013
	Rats	i.p.	100 mg/kg	↓oxidative stress, ↓MDA, ↑MnSOD	Wu et al., 2017
	Rats	i.p.	50–100 mg/kg	↓oxidative stress	Yamabe et al., 2006
	Mice	i.p.	100 mg/kg	↓oxidative damage, ↑Nrf2	Pan et al., 2017; Sun et al., 2017
AD	Rats	i.p.	40 mg/kg	↑glutathione peroxidase, ↓reactive oxygen species, ↓NO production	Baluchnejadmojarad and Roghani, 2011
	Rats	icv.	10 mg/kg	↑learning and memory, ↓malondialdehyde, ↓NO	Biasibetti et al., 2013

(↑) Increase, (↓) Decrease for STZ + EGCG group vs. STZ group.