Table 1.
List of some marine derived NRPs and their present status (Newman and Cragg, 2004; Fenical, 2006; Jimenez et al., 2009; Petit and Biard, 2013).
| Metabolite | Source | Pharmacological activity | R&D stage |
|---|---|---|---|
| Ecteinascidin 743 (YondelisTM) | Ecteinascidia turbinate (Sea squirt) | Anticancer | Market |
| Cephalosporine | Cephalosporium acremonium (Fungi) | Antibiotic | Market |
| Bengamide derivative (LAF389) | Jaspis sp. (Sponge) | Anticancer | Phase I |
| Hemiasterlin derivative (HTI-286) | Cymbastella sp. (Sponge) | Anticancer | Phase I |
| Dehydrodidemnine B (AplidineTM) | Aplidium albicans (Tunicate) | Anticancer | Phase II |
| Dolastatin 10 | Dolabella auricularia (Mollusc and Cyanobacteria) | Anticancer | Phase II |
| Kahalalide F | Elysia rufescens (Sea slug) | Antitumor | Phase II |
| Bryostatin 1 | Bugula neritina (Bryozoan) | Anticancer | Phase III |
| Diazonamide | Diazona angulata (Tunicate) | Anticancer | Preclinical |
| Thiocoraline | Mi Cromonospora marina (Bacteria) | Anticancer | Preclinical |
| Vitilevuamide | Didemnum cucliferum and Polysyncraton lithrostrotum (Tunicates) | Anticancer | Preclinical |