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. 2017 Oct 13;6(12):2062–2070. doi: 10.1002/sctm.17-0150

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© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Organoids can recapitulate normal and abnormal brain development. (A): A human cortical brain section from gestational week 11.5 displays a SOX2+ VZ and TBR2+ SVZ with Ki67+ proliferative cells present in both areas 26. (B): An organoid section labeled with SOX1 and TBR2 antibodies indicates the presence of progenitor regions with the stereotypical structure found in the embryonic brain. Note that organoids do not perfectly replicate the structure of the developing brain, as indicated by the presence of multiple, smaller proliferative zones in the organoid compared with one large proliferative region in the developing cortex. (A, B) Scale bars = 50 μm. Abbreviations: SVZ, subventricular zone; VZ, ventricular zone.