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. 2017 Oct 19;6(12):2160–2172. doi: 10.1002/sctm.17-0133

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© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Engraftment of human cells. (A): In situ hybridization of the human Alu sequence showing some human cells (brown—highlighted with red arrow) present in BMSC implants after 8 weeks, and mouse cells (purple), whereas no human cells were found in the ATSC group. Biomaterial is shown with an asterisk. Scale bars represent 100 μm. (B): Evaluation of human BMSC and ATSC number persisting in vivo on the scaffold, at T0, 24 hours, 1, and 4 weeks post‐graft, using human‐specific quantitative real‐time polymerase chain reaction assay. Data are represented as mean ± SE of the mean. *, p < .05. Abbreviations: ATSC, adipose tissue‐derived stem cells; BCP, biphasic calcium phosphate; BMSC, bone marrow‐derived stem cells.