Table 2.
Summary of acellular scaffolds listed in ClinicalTrials.gov for treatment of chondral or osteochondral defects in the knee.
| Product name | Company | Composition | Identifier |
|---|---|---|---|
| TruFit | Smith & Nephew, (Andover, MA) | Biphasic poly[d,l‐lactide]/glycolide and calcium sulfate polymer | NCT01246635 |
| Chondromimetic | Orthomimetics (Cambridge, U.K.) | Biphasic scaffold composed of collagen, calcium phosphate, and glycosaminoglycans | NCT01209390 |
| MaioRegen | FinCeramica Faenza S.p.A., (Faenza, Italy) | Tri‐layered scaffold. Type I collagen in the chondral layer, and differing concentrations of collagen and HA in the middle and deep layers | NCT01282034 |
| “BiCRI” BiPhasic Cartilage Repair Implant | Exactech Taiwan Ltd. (Gainsville, FL) | Bi‐phasic scaffold. Unknown composition | NCT01477008 |
| HYTOP | TRB Chemedica AG (Germany) | Bi‐layer bioresorbable matrix. Upper layer purified porcine splint‐skin, and lower layer of collagen fleece containing hyaluronan (HA) | NCT01791062 |
| BioMatrix CRD | Arthrex, (Naples, FL) | Bi‐layer scaffold with a top layer of type I collagen and a subchondral layer composed of β‐Tricalciumphosphate with PLA at the ratio of 80%–20% | NCT02309957 |
| BST‐CarGel | BioSyntech, (Quebec, Canada) | Chitosan‐glycerol phosphate‐based hydrogel scaffold whose active component is a polyglucosamine thrombogenic polysaccharide | NCT02981355 |
| GelrinC | Regentis, (Haifa, Israel) | Hydrogel composed of polyethelyne glycolated fibrinogen which polymerizes upon contact with ultraviolet light | |
| Chondro‐Gide | Geistlich Pharma AG (Wolhusen, Switzerland) | Bi‐layer type I/III collagen membrane | NCT02993510 |
| Agili‐C | CartiHeal Ltd. (Kfar Saba, Israel) | Bi‐phasic implant. The bone phase is composed of calcium carbonate in an aragonite crystalline form, and the cartilage phase is composed of modified aragonite and HA | NCT01471236 |
| CartiFill | Sewon Cellontech, (Seoul, Korea) | Atelocollagen, highly purified porcine derived type I collagen modified by removal of telopeptide | NCT02685917 |
Abbreviations: CRD, Cartilage Repair Device; HyA, hyaluronic acid; PLA, polylactic acid.