Figure 6.

Schematic diagram of MHAp scaffold-enhanced MC3T3-E1 cell proliferation, showing that MAPK/ERK signaling pathway was activated by the protein corona formed on the surface of MHAp scaffold to promote cell proliferation. Reprinted with permission from Zhu Y, Yang Q, Yang M, et al. Protein corona of magnetic hydroxyapatite scaffold improves cell proliferation via activation of mitogen-activated protein kinase signaling pathway. ACS Nano. 2017;11(4):3690–3704. Copyright 2017 American Chemical Society.¹⁰¹

Abbreviations: MHAp, magnetic hydroxyapatite; HAp, hydroxyapatite.