Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 26;6(12):2115–2125. doi: 10.1002/sctm.17-0138

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Tumor microenvironment consists not only of tumor cells and CSCs but are involved several types of cells and or processes, such as fibroblasts, migration of immune cells, angiogenesis, and matrix remodeling, MSCs thereby generating the so‐called tumor niche. Therefore, cancer cells and CSCs are intimately in contact with these cells, promoting tumourigenesis and cancer progression through several mechanisms among which tissue remodeling through matrix metalloproteinases, deposition of different extracellular matrix, liberation of pro‐angiogenic molecules, and secretion of soluble factors. Abbreviations: BMDC, bone‐marrow derived cells; CAF, cancer‐associated fibroblast; CSC, cancer stem cell; EPC, endothelial progenitor cells; MSC, mesenchymal stem cell.