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. 2017 Sep 22;5(6):668–677. doi: 10.1002/mgg3.324

Figure 2.

Figure 2

Results of the methylation analyses by deep bisulfite sequencing. (A) Comparative results for both amplicons covering the CUL7‐DMR. Each sample is represented in a single line. The average methylation over all analysed CpGs is given below the sample name on the left hand side together with the number of analysed reads. Every square represents an analysed CpG. The number inside gives the average methylation of the CpG over all analysed reads of the sample. Red is methylated, blue is unmethylated. (NC ‐ normal control blood sample; Case 2 – Case 2 blood sample; Placenta 1‐3 – first‐term placenta samples; Placenta 4‐6 – third‐term placenta samples). (B) Methylation result for the informative first‐term placenta 2 sample. The figure shows the result of the methylation analysis for the sample after allele separation using the informative SNP rs55890439. Methylation for allele A are displayed in the plot on the left and for allele G on the right. Each line represents a single read, each column a CpG. The number of analysed reads, the average methylation over all analysed reads, and CpGs as well as the allele is given above the plot. Red is methylated, blue is unmethylated.