Fig. 5.

SPECT/CT images of mice bearing PC-3 xenografts 96 h post injection. Mice were injected with 15 MBq ¹¹¹In-FnBPA5 a, c ¹¹¹In-scraFnBPA5 b, d, respectively. Images were acquired post mortem 96 h post injection. In a, b dominant kidney uptake of both ¹¹¹In-FnBPA5 and scrambled control peptide indicate unspecific clearance via the kidney. To assess additional information on peptide distribution within the body, kidneys were removed c and d. In c uptake in tumors and liver for ¹¹¹In-FnBPA5 is shown, whereas the ¹¹¹In-scraFnBPA5 control does not show any specific uptake in other organs. Results of SPECT/CT scans from individual subfigures are also shown in Supplementary Movies 1–4 showing 3D rotation movies of the respective scans