Table 1.

TRIM5 polymorphisms and HIV disease associations.

	Genotype	TRIM5α domain affected	Cohort population	HIV disease association	Reference
1	H43Y	RING	Central and South American	Diminished ability of TRIM5α to restrict HIV replication	(25)
2	43Y homozygote	RING	Hans and Dai Chinese	Allele appears paradoxically to protect against HIV infection	(26)
3	G249D	Linker 2 region between coiled-coil and PRYSPRY domains	Japanese and Indian	Associated with increased susceptibility to HIV-1 infection	(27)
4	R136Q	Coiled coil	Kenyan	Protects against infection	(28)
5	R136Q	Coiled coil	European Americans	More frequent in HIV-infected population	(29)
6	H43-136Q haplotype	RING and coiled coil	North-East Brazil	Increased frequency in HIV uninfected controls	(30)
7	G110R	B-box	Japanese	Increased susceptibility to HIV infection	(31)