Table 1.
Blood coagulation parameters and thrombin generation parameters of LZR and MSZR at 25 and 80 weeks of age.
| 25 week-old | 80 week-old | ANOVA | |||||
|---|---|---|---|---|---|---|---|
| LZR | MSZR | LZR | MSZR | Strain | Age | Interaction | |
| n | 9 | 10 | 12 | 9 | |||
| Platelets (103/mm3) | 574 ± 37 | 789 ± 34* | 633 ± 29 | 834 ± 63* | ≤0.0001 | 0.009 | 0.013 |
| F1+2 (pmol/l) | 4.1 ± 0.5 | 7.9 ± 1.0* | 5.8 ± 1.2 | 5.5 ± 0.9 | 0.009 | 0.7 | 0.05 |
| TF (pM) | 0.3 ± 0.1 | 12.2 ± 1.7* | 2.0 ± 0.4 | 9.9 ± 1.5* | ≤0.0001 | 0.8 | 0.09 |
| TFPI activity (U/ml) | 4.9 ± 0.2 | 11.2 ± 0.2* | 5.4 ± 0.2 | 9.9 ± 0.6*# | ≤0.0001 | 0.3 | 0.01 |
| FVIII (%) | 104 28 | 190 34 | 124 28 | 466 52*# | ≤0.0001 | 0.002 | 0.001 |
| Prothrombin (%) | 94 ± 3 | 223 ± 19* | 155 ± 14# | 264 ± 16* | ≤0.0001 | 0.002 | 0.5 |
| AT (%) | 129 ± 2 | 125 ± 2 | 127 ± 1 | 123 ± 3 | 0.04 | 0.5 | 0.9 |
| Fibrinogen (g/l) | 2.8 ± 0.1 | 4.0 ± 0.2* | 3.1 ± 0.1 | 4.9 ± 0.2*# | ≤0.0001 | 0.0003 | 0.2 |
| n | 11 | 11 | 10 | 7 | |||
| Lag time (min) | 1.5 ± 0.1 | 1.7 ± 0.1 | 1.4 ± 0.1 | 1.5 ± 0.1 | 0.09 | 0.4 | 0.6 |
| Peak (nM) | 99 ± 8 | 121 ± 9 | 102 ± 10 | 117 ± 15 | 0.07 | 0.98 | 0.7 |
| Time to peak (min) | 4.4 ± 0.1 | 5.2 ± 0.3* | 4.1 ± 0.1 | 5.3 ± 0.2* | ≤0.0001 | 0.6 | 0.3 |
| ETP (nM.min) | 395 ± 37 | 549 ± 52* | 362 ± 34 | 553 ± 76* | 0.001 | 0.8 | 0.8 |
| Velocity (nM/min) | 35 ± 3 | 37 ± 4 | 40 ± 4 | 31 ± 4 | 0.6 | 0.98 | 0.2 |
Results are mean ± standard error to the mean.
*
p < 0.05, SMZR vs. LZR at the same age;
#
p < 0.05, 80 vs. 25 week-old rats in the same strain. F1+2, fragment 1+2; TF, tissue factor; TFPI, tissue factor pathway inhibitor; AT, antithrombin; ETP, endogenous thrombin potential.