Figure 4.

Associations between residualized changes in white matter diffusion measures, neuropsychological measures, and multiple sleep latency test (MSLT) scores following BLT and ALT. For BLT and ALT groups, correlations found between residualized changes in NQA and neuropsychological function measures (DM) [BLT: (A,B), ALT: (C,D)], and between residualized changes in NQA and MSLT scores [BLT: (E), ALT: (F)] are reported. Significant negative correlations between residualized changes in Repeatable Battery for the Assessment of Neuropsychological Status DM scores and NQA measures were found for fibers crossing the body of the corpus callosum (CC) (A) and thalamus (B) for BLT group. No significant correlations were found for ALT group, including for fibers crossing the body of the CC (C) and thalamus (D). Significant negative correlations between residualized changes in sleep onset latency during the first MSLT administration and NQA measures were also found for fibers crossing the left anterior corona radiata (ACR) (E) for BLT group but not for ALT group (F). BLT, blue-light therapy; ALT, amber-light therapy, DM, delayed memory.