Figure 2.

Prepulse inhibition for a gap in otherwise continuous background noise can be used for rejection criteria. (A) Schematic of the acoustic stimuli. The prepulse is a 10 ms silent gap that commences 10–300 ms prior to the startle stimulus. (B) The gap is a highly effective prepulse in all mice when presented at 10 ms lead-time before the ASR. Strains vary by how effective the prepulse is beyond 10 ms, though the response is stable between 60 and 100 ms. (C) Criterion for rejecting individual mice. If the non-parametric A′ measure was less than 80% for the 10 ms gap condition, the mouse would be rejected as an unreliable responder. Strains varied in the proportion of rejected animals. Error bars are SEMs.