Table 3.

External signatures

Metabolites, species, sample origin, and references are listed for 11 external signatures (Ext 1–11). carn, carnitine; Cer, ceramide; Glx, glutamate/glutamine.

Signature	Ext 1	Ext 2	Ext 3	Ext 4	Ext 5	Ext 6	Ext 7	Ext 8	Ext 9	Ext 10	Ext 11
Refs.	35, 36	44	38	45	37	41	42	46	39	43	40
Species	Mouse	Human	Human	Human	Human	Human	Human	Human	Human	Human	Human
Sample	Adipose/Liver	Plasma	Plasma	Plasma	Serum	Muscle	Serum	Plasma	Plasma	Serum	Muscle
Metabolites	C16-Cer	Val	Sum Cer	Val	Val	Sum Cer	Gly	Val	Sum Cer	Val	C18-Cer
		Leu/Ile	C18-Cer	Leu/Ile	Leu/Ile	C14-Cer		Leu/Ile	C14-Cer	Leu/Ile
		Gly	C20-Cer	C3-carn	C3-carn	C16-Cer		Ala		C3-carn
		Phe	C24-Cer	C5-carn	C5-carn	C24:1-Cer		Glx		Phe
		Glx	C24:1-Cer		Ala			Phe		Tyr
					Glx			Tyr
					Met			Pyruvate
					Phe			Malonyl/hydroxy-butyryl-CoA
					Tyr