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Cytotoxicity of kleboxymycin and tilivalline. A, results of cytotoxicity assessment (TC50) from an MTT-based cell culture assay, showing a >9-fold lower TC50 value of kleboxymycin relative to tilivalline. B, CPE of 1.56 μm tilivalline and 1.56 μm kleboxymycin on HEp-2 cells on day 2 post-treatment. Cells exposed to tilivalline show minimal CPE relative to minimal control, but those treated with kleboxymycin showed significant cell rounding. ×20 magnification.
